Sinnarizin
Sinnarizin, difenilmetilpiperazin grubunun bir antihistamin ve kalsiyum kanal blokeridir.[1] Araç tutması,[2] kemoterapi,[3] vertigo,[4] veya Ménière hastalığı nedeniyle bulantı ve kusma için reçete edilir.[5]
Sinnarizin ilk olarak 1955 yılında Janssen Pharmaceutica tarafından R1575 olarak sentezlenmiştir.
Kaynakça değiştir
- ^ "Drug-induced parkinsonism: cinnarizine and flunarizine are potent uncouplers of the vacuolar H+-ATPase in catecholamine storage vesicles". Neuropharmacology. 38 (6): 879-82. June 1999. doi:10.1016/s0028-3908(98)00233-0. PMID 10465691.
- ^ "Central effects of cinnarizine: restricted use in aircrew". Aviation, Space, and Environmental Medicine. 73 (6): 570-4. June 2002. PMID 12056673.
- ^ "Cinnarizine for prevention of nausea and vomiting during platin chemotherapy". Acta Oncologica. 30 (6): 731-4. 1991. doi:10.3109/02841869109092448. PMID 1958394.
- ^ "New approaches to the management of peripheral vertigo: efficacy and safety of two calcium antagonists in a 12-week, multinational, double-blind study". Otology & Neurotology. 23 (3): 357-63. May 2002. doi:10.1097/00129492-200205000-00023. PMID 11981396.
- ^ "Inhibition of voltage-gated calcium currents in type II vestibular hair cells by cinnarizine". Naunyn-Schmiedeberg's Archives of Pharmacology. 369 (6): 570-5. June 2004. doi:10.1007/s00210-004-0936-3. PMID 15138660.