CHKA

Kolin kinaz alfa, insanlarda CHKA geni tarafından kodlanan bir enzimdir.

CHKA
Uygun yapılar PDB Ortolog araması: PDBe RCSB PDB kimlik kodlarının listesi 2CKO, 2CKP, 2CKQ, 2I7Q, 3F2R, 3G15, 3ZM9, 4BR3, 4CG8, 4CG9, 4CGA, 4DA5, 5AFV, 5EQE, 5EQP, 5EQY, 5FTG
Tanımlayıcılar
Başka adlar	CHKA
Dış kimlikler	OMIM: 118491 MGI: 107760 HomoloGene: 88575 GeneCards: CHKA
Enzim Komisyon numarası	2.7.1.82
Gen yerleşimi (İnsan) Krom. 11. Kromozom (insan) Bant 11q13.2 Başlangıç 68,052,859 bç Bitiş 68,121,444 bç
RNA ekspresyonu deseni Daha çok ekspresyon verisi başvurusu
Gen ontolojisi Moleküler işlevi • transferase activity • nucleotide binding • protein homodimerization activity • cholinesterase activity • signal transducer activity • choline binding • kinase activity • ATP binding • ethanolamine kinase activity • choline kinase activity Hücresel bileşeni • sitoplazma • Sitozol Biyolojik süreci • lipid transport • ethanolamine metabolic process • choline metabolic process • Protein fosforilasyonu • lipid metabolism • response to 3-methylcholanthrene • phospholipid biosynthetic process • response to toxic substance • CDP-choline pathway • GO:0072468 Sinyal transdüksiyonu • phosphatidylcholine biosynthetic process • phosphatidylethanolamine biosynthetic process Kaynaklar:Amigo / QuickGO
Ortologlar
Türler	İnsan	Fare
Entrez	1119	12660
Ensembl	ENSG00000110721	ENSMUSG00000024843
UniProt	P35790	O54804
RefSeq (mRNA)	NM_001277 NM_212469 NM_001376219 NM_001376220 NM_001376221 NM_001376222	NM_001025566 NM_001271496 NM_013490
RefSeq (protein)	NP_001268 NP_997634 NP_001363148 NP_001363149 NP_001363150 NP_001363151	NP_001258425 NP_038518
Yerleşim (UCSC)	Krom. 11: 68.05 – 68.12 Mb	n/a
PubMed araması
Vikiveri
İnsan'ı Gör/Düzenle Fare'yi Gör/Düzenle

Fosfatidilkolin biyosentezi için ana yol, CDP-kolin yolu üzerinden gerçekleşir. Bu gen tarafından kodlanan protein, dizideki ilk enzimdir ve düzenleyici bir rol oynayabilir. Kodlanan protein ayrıca etanolaminin fosforilasyonunu katalize eder. Bu gen için farklı izoformları kodlayan iki transkript türevi bulunmuştur.

Melanositik hücrelerde CHKA gen dışa vurumu MITF tarafından düzenlenebilir.

Dış bağlantılar

• İnsan CHKA 30 Aralık 2019 tarihinde Wayback Machine sitesinde arşivlendi. genomu yerleşimi ve CHKA geni ayrıntıları UCSC Genom Tarayıcısında.

Konuyla ilgili yayınlar

• Spanner S, Ansell GB (1979). "Choline kinase and ethanolamine kinase activity in the cytosol of nerve endings from rat forebrain". Biochem. J. 178 (3). ss. 753-60. PMC 1186576 $2. PMID 36885. 
• Spanner S, Ansell GB (1978). "Choline and ethanolamine kinase activity in the cytoplasm of nerve endings from rat forebrain". Adv. Exp. Med. Biol. Cilt 101. ss. 237-45. doi:10.1007/978-1-4615-9071-2_23. PMID 208357. 
• Kaplan O, Cohen JS (1994). "Lymphocyte activation-31P magnetic resonance studies of energy metabolism and phospholipid pathways". ImmunoMethods. 4 (2). ss. 139-47. doi:10.1006/immu.1994.1015. PMID 8069533. 
• Price DJ, Rivnay B, Fu Y (1997). "Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes". J. Biol. Chem. 272 (9). ss. 5915-20. doi:10.1074/jbc.272.9.5915. PMID 9038210. 
• Ross BM, Moszczynska A, Blusztajn JK (1997). "Phospholipid biosynthetic enzymes in human brain". Lipids. 32 (4). ss. 351-8. doi:10.1007/s11745-997-0044-x. PMID 9113621. 
• Nakagami K, Uchida T, Ohwada S (1999). "Increased choline kinase activity and elevated phosphocholine levels in human colon cancer". Jpn. J. Cancer Res. 90 (4). ss. 419-24. doi:10.1111/j.1349-7006.1999.tb00764.x. PMC 5926083 $2. PMID 10363580. 
• Ramírez de Molina A, Penalva V, Lucas L, Lacal JC (2002). "Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K". Oncogene. 21 (6). ss. 937-46. doi:10.1038/sj.onc.1205144. PMID 11840339. 
• Dubois T, Howell S, Zemlickova E, Aitken A (2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS Lett. 517 (1-3). ss. 167-71. doi:10.1016/S0014-5793(02)02614-5. PMID 12062430. 
• Ramírez de Molina A, Gutiérrez R, Ramos MA (2002). "Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy". Oncogene. 21 (27). ss. 4317-22. doi:10.1038/sj.onc.1205556. PMID 12082619. 
• Ramírez de Molina A, Rodríguez-González A, Gutiérrez R (2002). "Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers". Biochem. Biophys. Res. Commun. 296 (3). ss. 580-3. doi:10.1016/S0006-291X(02)00920-8. PMID 12176020. 
• Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15.000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26). ss. 16899-903. doi:10.1073/pnas.242603899. PMC 139241 $2. PMID 12477932. 
• Ota T, Suzuki Y, Nishikawa T (2004). "Complete sequencing and characterization of 21.243 full-length human cDNAs". Nat. Genet. 36 (1). ss. 40-5. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B). ss. 2121-7. doi:10.1101/gr.2596504. PMC 528928 $2. PMID 15489334. 
• Gallego-Ortega D, Ramirez De Molina A, Gutierrez R (2006). "Generation and characterization of monoclonal antibodies against choline kinase alpha and their potential use as diagnostic tools in cancer" (PDF). Int. J. Oncol. 29 (2). ss. 335-40. doi:10.3892/ijo.29.2.335. PMID 16820874. 20 Ağustos 2017 tarihinde kaynağından arşivlendi (PDF). Erişim tarihi: 8 Mart 2020. 
• Enaw JO, Zhu H, Yang W (2007). "CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population". BMC Medicine. Cilt 4. s. 36. doi:10.1186/1741-7015-4-36. PMC 1770928 $2. PMID 17184542.