ARHGAP1

ARHGAP1
Uygun yapılar
PDB	Ortolog araması: PDBe RCSB
PDB kimlik kodlarının listesi
	1AM4, 1GRN, 1OW3, 1RGP, 1TX4, 2NGR
Tanımlayıcılar
Başka adlar	ARHGAP1
Dış kimlikler	OMIM: 602732 MGI: 2445003 HomoloGene: 20909 GeneCards: ARHGAP1
Gen yerleşimi (İnsan)
Krom.	11. Kromozom (insan)
Bitiş	46,700,619 bç
RNA ekspresyonu deseni
	; ;
	Daha çok ekspresyon verisi başvurusu
Gen ontolojisi
Moleküler işlevi	• SH3 domain binding; • GO:0001948, GO:0016582 protein bağlanması; • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity; • cadherin binding;
Hücresel bileşeni	• Sitozol; • extracellular exosome; • sitoplazma; • endosome membrane; • perinuclear region of cytoplasm; • sorting endosome; • membrane; • integral component of membrane;
Biyolojik süreci	• regulation of small GTPase mediated signal transduction; • Rho protein signal transduction; • GO:0072468 Sinyal transdüksiyonu; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • small GTPase mediated signal transduction; • positive regulation of signal transduction; • transferrin transport; • iron ion import across cell outer membrane; • negative regulation of endocytic recycling; • endosomal transport;
	Kaynaklar:Amigo / QuickGO
Ortologlar
	392
	228359
	ENSG00000175220
	ENSMUSG00000027247
	Q07960
	Q5FWK3
	NM_004308
	NM_001145902; NM_146124; NM_001359970
	NP_004299
	NP_001139374; NP_666236; NP_001346899
	Vikiveri
İnsan'ı Gör/Düzenle	Fare'yi Gör/Düzenle

Rho GTPaz etkinleştirici protein 1, insanlarda ARHGAP1 geni tarafından kodlanan bir enzimdir.^[4]^[5]

Etkileşimler değiştir

Aşağıdakilerin ARHGAP1 ile etkileşime girdiği gösterilmiştir:

BNIP2,^[6]
CDC42^[7]^[8]^[9]^[10] ve
RHOA.^[11]^[12]

Konuyla ilgili yayınlar değiştir

Diekmann D, Brill S, Garrett MD, Totty N, Hsuan J, Monfries C, Hall C, Lim L, Hall A (1991). "Bcr encodes a GTPase-activating protein for p21rac". Nature. 351 (6325). ss. 400-2. doi:10.1038/351400a0. PMID 1903516.
Garrett MD, Major GN, Totty N, Hall A (1991). "Purification and N-terminal sequence of the p21rho GTPase-activating protein, rho GAP". Biochem. J. 276 (Pt 3) (3). ss. 833-6. PMC 1151079 $2. PMID 1905930.
Barfod ET, Zheng Y, Kuang WJ, Hart MJ, Evans T, Cerione RA, Ashkenazi A (1993). "Cloning and expression of a human CDC42 GTPase-activating protein reveals a functional SH3-binding domain". J. Biol. Chem. 268 (35). ss. 26059-62. PMID 8253717.
Aspenström P, Lindberg U, Hall A (1996). "Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome". Curr. Biol. 6 (1). ss. 70-5. doi:10.1016/S0960-9822(02)00423-2. PMID 8805223.
Barrett T, Xiao B, Dodson EJ, Dodson G, Ludbrook SB, Nurmahomed K, Gamblin SJ, Musacchio A, Smerdon SJ, Eccleston JF (1997). "The structure of the GTPase-activating domain from p50rhoGAP". Nature. 385 (6615). ss. 458-61. doi:10.1038/385458a0. PMID 9009196.
Hu KQ, Settleman J (1997). "Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation". EMBO J. 16 (3). ss. 473-83. doi:10.1093/emboj/16.3.473. PMC 1169651 $2. PMID 9034330.
Rittinger K, Walker PA, Eccleston JF, Nurmahomed K, Owen D, Laue E, Gamblin SJ, Smerdon SJ (1997). "Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP". Nature. 388 (6643). ss. 693-7. doi:10.1038/41805. PMID 9262406.
Zhang B, Wang ZX, Zheng Y (1997). "Characterization of the interactions between the small GTPase Cdc42 and its GTPase-activating proteins and putative effectors. Comparison of kinetic properties of Cdc42 binding to the Cdc42-interactive domains". J. Biol. Chem. 272 (35). ss. 21999-2007. doi:10.1074/jbc.272.35.21999. PMID 9268338.
Li R, Zhang B, Zheng Y (1997). "Structural determinants required for the interaction between Rho GTPase and the GTPase-activating domain of p190". J. Biol. Chem. 272 (52). ss. 32830-5. doi:10.1074/jbc.272.52.32830. PMID 9407060.
Zhang B, Zheng Y (1998). "Regulation of RhoA GTP hydrolysis by the GTPase-activating proteins p190, p50RhoGAP, Bcr, and 3BP-1". Biochemistry. 37 (15). ss. 5249-57. doi:10.1021/bi9718447. PMID 9548756.
Low BC, Lim YP, Lim J, Wong ES, Guy GR (1999). "Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42". J. Biol. Chem. 274 (46). ss. 33123-30. doi:10.1074/jbc.274.46.33123. PMID 10551883.
Graham DL, Eccleston JF, Chung CW, Lowe PN (1999). "Magnesium fluoride-dependent binding of small G proteins to their GTPase-activating proteins". Biochemistry. 38 (45). ss. 14981-7. doi:10.1021/bi991358e. PMID 10555980.
Low BC, Seow KT, Guy GR (2000). "Evidence for a novel Cdc42GAP domain at the carboxyl terminus of BNIP-2". J. Biol. Chem. 275 (19). ss. 14415-22. doi:10.1074/jbc.275.19.14415. PMID 10799524.
Low BC, Seow KT, Guy GR (2000). "The BNIP-2 and Cdc42GAP homology domain of BNIP-2 mediates its homophilic association and heterophilic interaction with Cdc42GAP". J. Biol. Chem. 275 (48). ss. 37742-51. doi:10.1074/jbc.M004897200. PMID 10954711.
Zhou YT, Soh UJ, Shang X, Guy GR, Low BC (2002). "The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence". J. Biol. Chem. 277 (9). ss. 7483-92. doi:10.1074/jbc.M109459200. PMID 11741952.
Fidyk NJ, Cerione RA (2002). "Understanding the catalytic mechanism of GTPase-activating proteins: demonstration of the importance of switch domain stabilization in the stimulation of GTP hydrolysis". Biochemistry. 41 (52). ss. 15644-53. doi:10.1021/bi026413p. PMID 12501193.
Qin W, Hu J, Guo M, Xu J, Li J, Yao G, Zhou X, Jiang H, Zhang P, Shen L, Wan D, Gu J (2003). "BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis". Biochem. Biophys. Res. Commun. 308 (2). ss. 379-85. doi:10.1016/S0006-291X(03)01387-1. PMID 12901880.
Shang X, Zhou YT, Low BC (2003). "Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1". J. Biol. Chem. 278 (46). ss. 45903-14. doi:10.1074/jbc.M304514200. PMID 12944407.

Dış bağlantılar değiştir

Human ARHGAP1 30 Aralık 2019 tarihinde Wayback Machine sitesinde arşivlendi. genome location and ARHGAP1^{[ölü/kırık bağlantı]} gene details page in the UCSC Genome Browser.

Kaynakça değiştir

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175220 - Ensembl, May 2017
^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases". J. Biol. Chem. 269 (2). Şubat 1994. ss. 1137-42.
^ "Entrez Gene: ARHGAP1 Rho GTPase activating protein 1". 5 Aralık 2010 tarihinde kaynağından arşivlendi.
^ "The BNIP-2 and Cdc42GAP homology domain of BNIP-2 mediates its homophilic association and heterophilic interaction with Cdc42GAP". J. Biol. Chem. 275 (48). Aralık 2000. ss. 37742-51.
^ "Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42". J. Biol. Chem. 274 (46). Kasım 1999. ss. 33123-30.
^ "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1). Ocak 1998. ss. 149-58.
^ "Structural determinants required for the interaction between Rho GTPase and the GTPase-activating domain of p190". J. Biol. Chem. 272 (52). Aralık 1997. ss. 32830-5.
^ "Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA". J. Biol. Chem. 273 (15). Nisan 1998. ss. 8776-82.
^ "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). Ekim 2005. ss. 1173-8.
^ "Regulation of RhoA GTP hydrolysis by the GTPase-activating proteins p190, p50RhoGAP, Bcr, and 3BP-1". Biochemistry. 37 (15). Nisan 1998. ss. 5249-57.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175220 - Ensembl, May 2017

[2] "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8288572-4] "Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases". J. Biol. Chem. 269 (2). Şubat 1994. ss. 1137-42.

[entrez-5] "Entrez Gene: ARHGAP1 Rho GTPase activating protein 1". 5 Aralık 2010 tarihinde kaynağından arşivlendi.

[pmid10954711-6] "The BNIP-2 and Cdc42GAP homology domain of BNIP-2 mediates its homophilic association and heterophilic interaction with Cdc42GAP". J. Biol. Chem. 275 (48). Aralık 2000. ss. 37742-51.

[pmid10551883-7] "Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42". J. Biol. Chem. 274 (46). Kasım 1999. ss. 33123-30.

[pmid9427749-8] "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1). Ocak 1998. ss. 149-58.

[pmid9407060-9] "Structural determinants required for the interaction between Rho GTPase and the GTPase-activating domain of p190". J. Biol. Chem. 272 (52). Aralık 1997. ss. 32830-5.

[pmid9535855-10] "Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA". J. Biol. Chem. 273 (15). Nisan 1998. ss. 8776-82.

[pmid16189514-11] "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). Ekim 2005. ss. 1173-8.

[pmid9548756-12] "Regulation of RhoA GTP hydrolysis by the GTPase-activating proteins p190, p50RhoGAP, Bcr, and 3BP-1". Biochemistry. 37 (15). Nisan 1998. ss. 5249-57.

[4]

[5]

[1]

[2]

[3]

[6]

[7]

[8]

[9]

[10]

[11]

[12]