Glikoliz: Revizyonlar arasındaki fark

 

== Tarihi ==

In 1897 [[Eduard Buchner]] found that ''extracts'' of certain cells can cause fermentation. In 1905 [[Arthur Harden]] and [[William John Young|William Young]] determined that a heat-sensitive high-molecular-weight subcellular fraction (the enzymes) and a heat-insensitive low-molecular-weight cytoplasm fraction (ADP, ATP and NAD⁺ and other [[Cofactor (biochemistry)|cofactors]]) are required together for fermentation to proceed. The details of the pathway were eventually determined by 1940, with a major input from [[Otto Meyerhof]] and some years later by [[Luis Leloir]]. The biggest difficulties in determining the intricacies of the pathway were due to the very short lifetime and low steady-state concentrations of the intermediates of the fast glycolytic reactions.