John Gurdon: Revizyonlar arasındaki fark
| [kontrol edilmiş revizyon] | [kontrol edilmemiş revizyon] |
İçerik silindi İçerik eklendi
Değişiklik özeti yok |
k →Referanslar: şablon değiştirme |
||
1. satır:
{{düzenle|Ekim 2012}}
{{Diğer anlamı|Gurdon}}
<!--
{{Infobox scientist
|
|
|
|
|
|
|
|
|
| work_institutions = [[University of Oxford]]<br>[[University of Cambridge]]<br>[[California Institute of Technology]]
| alma_mater = [[Christ Church, Oxford]]
| thesis_title = Studies on nucleocytoplasmic relationships during differentiation in vertebrates
| thesis_url = http://www.theses.com
| thesis_year = 1961
| doctoral_advisor = Michael Fischberg<ref name="godfather"/>
|
| known_for = Nuclear transfer, cloning
| author_abbrev_bot =
| author_abbrev_zoo =
| prizes = [[Wolf Prize in Medicine]] (1989)<br /> [[Albert Lasker Award for Basic Medical Research|Albert Lasker Basic Medical Research Award]] (2009) <br/>[[Nobel Prize in Physiology or Medicine]] (2012)
|
| website = {{URL|http://www.gurdon.cam.ac.uk/gurdon.html}}<br>{{URL|http://www.zoo.cam.ac.uk/zoostaff/gurdon.htm}}
}}
-->
'''Sir John Bertrand Gurdon (JBG)'''<!--, [[Fellow of the Royal Society|FRS]]--> (d. 2 Ekim 1933) Britanyalı biyolog ve 2012'de [[Nobel Fizyoloji veya Tıp Ödülü]] sahibi<!--[[developmental biology|developmental biologist]]. He is best known for his pioneering research in [[Somatic cell nuclear transfer|nuclear transplantation]]<ref>{{cite doi|10.1073/pnas.1337135100}}</ref><ref>{{cite pmid|16704337}}</ref><ref>{{cite doi|10.1126/science.1160810}}</ref> and [[cloning]].<ref>{{cite pmid|19132124}}</ref><ref name="godfather">{{cite pmid|18426972}}</ref><ref>{{cite pmid|14521852}}</ref><ref>{{cite pmid|10761853}}</ref> He was awarded the [[Lasker Award]] in 2009 and the [[Nobel Prize for Physiology or Medicine]] in 2012.<ref>{{cite web|url=http://www.nobelprize.org/nobel_prizes/medicine/laureates/2012/press.html|publisher=Nobel Media AB|date=2012-10-08|title=The Nobel Prize in Physiology or Medicine - 2012 Press Release}}</ref>-->
==Career==
<!--
After attending [[Eton College]], Gurdon went up to [[Christ Church, Oxford]], to study [[classics]] but switched to [[zoology]]. For his [[D.Phil.]] he studied nuclear transplantation in the frog ''[[Xenopus]]''<ref name="gurdonphd">{{cite thesis |degree=DPhil |first=John|last=Gurdon |title=Studies on nucleocytoplasmic relationships during differentiation in vertebrates |publisher=University of Oxford |date=1961 |url=http://www.theses.com|authorlink=John Gurdon}}</ref> with Michael Fischberg at Oxford. Following postdoctoral work at [[Caltech]].<ref name="Rodney Porter">[http://www.bioch.ox.ac.uk/glycob/rodney_porter_lectures/1999/gurdon.html Rodney Porter Lectures: Biography]</ref> he returned to England and his early posts were at the Department of Zoology of the [[University of Oxford]] (1962–71).
Gurdon has spent much of his research career at the [[University of Cambridge]], UK, first at the [[Medical Research Council (United Kingdom)|MRC]] [[Laboratory of Molecular Biology]] (1971–83) and then at the Department of Zoology, (1983–date). In 1989, he was a founding member of the Wellcome/CRC Institute for Cell Biology and Cancer (later Wellcome/CR UK) in Cambridge, and was its Chair until 2001. He was a member of the [[Nuffield Council on Bioethics]] 1991-1995, and Master of [[Magdalene College, Cambridge]] from 1995 to 2002.
-->
==Research==
===Nuclear transfer===
<!--
In 1958, Gurdon, then at the [[University of Oxford]], successfully cloned a frog using intact [[cell_nucleus|nuclei]] from the somatic cells of a [[Xenopus]] tadpole.<ref>{{cite doi|10.1038/182064a0| issue=4627}}</ref><ref>{{cite pmid|13951335}}</ref> This was an important extension of work of Briggs and King in 1952 on transplanting nuclei from embryonic [[blastula]] cells.<ref>{{cite journal| journal=Proc Natl Acad Sci U S A. |date=1952 May|volume= 38|pages=455–463| pmid= 16589125
|title=Transplantation of Living Nuclei From Blastula Cells into Enucleated Frogs' Eggs|author=Robert Briggs and Thomas J. King| doi=10.1073/pnas.38.5.455| issue=5| pmc=1063586}}</ref>
Gurdon’s experiments captured the attention of the scientific community and the tools and techniques he developed for nuclear transfer are still used today. The term clone<ref>{{cite doi|10.1038/45429}}</ref> (from the Greek word klōn, meaning “twig”) had already been in use since the beginning of the 20th century in reference to plants. In 1963 the British biologist [[J. B. S. Haldane]], in describing Gurdon’s results, became one of the first to use the word clone in reference to animals.
-->
===Messenger RNA expression===
<!--
Gurdon and colleagues also pioneered the use of [[Xenopus]] (genus of highly aquatic frog) eggs and oocytes to translate microinjected [[messenger RNA]] molecules,<ref>{{cite doi|10.1038/233177a0}}</ref> a technique which has been widely used to identify the proteins encoded and to study their function.
-->
===Recent research===
<!--
Gurdon's recent research has focused on analysing intercellular signalling factors involved in [[cell differentiation]], and on elucidating the mechanisms involved in reprogramming the nucleus in transplantation experiments, including [[DNA methylation|demethylation]] of the transplanted DNA.<ref>{{cite doi|10.1038/ncb1176|issue=10}}</ref>
-->
==Ödüller (Honours and awards)==
<!--
Gurdon was made a Fellow of the [[Royal Society]] in 1971, and was knighted in 1995. In 2004, the [[Wellcome Trust]]/[[Cancer Research UK]] Institute for Cell Biology and Cancer was renamed the [[Gurdon Institute]]<ref>{{cite web |url=http://www.gurdon.cam.ac.uk/ |title=The Gurdon Institute |format= |work= |accessdate=2011-07-26}}</ref> in his honour. He has also received numerous awards, medals and honorary degrees.<ref name="Rodney Porter" /> He has been awarded the 2009 Albert Lasker Basic Medical Research award.
-->
===Nobel Ödülü===
<!--
In 2012 Gurdon was awarded, jointly with [[Shinya Yamanaka]], the [[Nobel Prize for Physiology or Medicine]] ''"for the discovery that mature cells can be reprogrammed to become pluripotent"''.<ref name="NobelPrize">{{cite web | url=http://www.nobelprize.org/nobel_prizes/medicine/laureates/2012/ | title=The Nobel Prize in Physiology or Medicine 2012 | publisher=NobelPrize.org | date=October 08, 2012 | accessdate=October 08, 2012}}</ref>
-->
==Referanslar==
{{Kaynakça|2}}
==Dış bağlantarı==
{{Commonscat|John Gurdon}}
*[http://www.alanmacfarlane.com/ancestors/gurdon.htm John Gurdon interviewed by Alan Macfarlane 20th August 2008 (film)]
*[http://www.worldscibooks.com/medsci/7565.html Wolf Prize in Medicine 1978-2008 edited by John Gurdon (film)]
<!--
{{s-start}}
{{s-aca}}
{{succession box
| before = [[David Chilton Phillips]]
| title = [[Fullerian Professor of Physiology]]
| years = 1985–1991
| after = [[Anne McLaren]]
}}
{{succession box
| title=[[Dean (university)|Master]] of [[Magdalene College, Cambridge]]
| before=[[David Calcutt|Sir David Calcutt]]
| after=[[Duncan Robinson]]
| years=1994–2002
}}
{{end}}
{{Copley Medallists 2001-2050}}
{{Wolf Prize in Medicine}}
{{2012 Nobel Prize winners}}
-->
{{İngiliz-taslak}}
{{biyolog-taslak}}
{{DEFAULTSORT:Gurdon, John Bertrand}}
[[Kategori:1933 doğumlular]]
<!--
[[Category:Place of birth missing (living people)]] doğum yeri bilmiyorum :(
-->
[[Kategori:Britanyalı Nobel Ödülü sahipleri]]
[[Kategori:Britanyalı agnostikler]]
[[Kategori:İngiliz biyologlar]]
<!--
[[Category:English Nobel laureates]]
-->
[[Kategori:Oxford Üniversitesi mezunları]]
<!--
[[Category:Alumni of Christ Church, Oxford]]
-->
[[Kategori:Cambridge Üniversitesi öğretim üyeleri]]
<!--
[[Category:Fellows of Churchill College, Cambridge]]
-->
[[Kategori:Royal Society üyeleri]]
<!--
[[Category:Fullerian Professors of Physiology]]
[[Category:Knights Bachelor]]
[[Category:Masters of Magdalene College, Cambridge]]
-->
[[Kategori:Fransız Bilimler Akademisi üyeleri]]
[[Kategori:ABD Bilimler Ulusal Akademisi üyeleri]]
[[Kategori:Nobel Fizyoloji veya Tıp Ödülü sahipleri]]
[[Kategori:
<!--
[[Category:Royal Medal winners]]
[[Category:Wolf Prize in Medicine laureates]]
-->
[[Kategori:Yaşayan insanlar]]
[[
[[arz:چون جيردون]]
[[be:Джон Гёрдан]]
[[bn:জন গার্ডন]]
[[ca:John B. Gurdon]]
[[cs:John Gurdon]]
[[da:John Gurdon]]
[[de:John Gurdon]]
[[en:John Gurdon]]
[[es:John Gurdon]]
[[fi:John Gurdon]]
[[fr:John Gurdon]]
[[he:ג'ון גרדון]]
[[hu:John B. Gurdon]]
[[id:John Gurdon]]
[[it:John Gurdon]]
[[ja:ジョン・ガードン (生物学者)]]
[[ko:존 거든]]
[[la:Ioannes Gurdon]]
[[nds:John Bertrand Gurdon]]
[[nl:John Gurdon]]
[[no:John Gurdon]]
[[pl:John Gurdon]]
[[pnb:جان گرڈن]]
[[pt:John Gurdon]]
[[ro:John B. Gurdon]]
[[ru:Гёрдон, Джон]]
[[scn:John Gurdon]]
[[simple:John Gurdon]]
[[sl:John Bertrand Gurdon]]
[[sr:Џон Гердон]]
[[sv:John Gurdon]]
[[ta:சான் பி. குர்தோன்]]
[[tt:Джон Һердон]]
[[uk:Джон Гердон]]
[[vi:John Gurdon]]
[[yo:John Gurdon]]
[[zh:约翰·格登]]
| |||