CD3D

CD3D
Uygun yapılar
PDB	Ortolog araması: PDBe RCSB
PDB kimlik kodlarının listesi
	1XIW
Tanımlayıcılar
Başka adlar	CD3D
Dış kimlikler	OMIM: 186790 MGI: 88331 HomoloGene: 585 GeneCards: CD3D
Gen yerleşimi (İnsan)
Krom.	11. Kromozom (insan)
Bitiş	118,342,705 bç
RNA ekspresyonu deseni
	Daha çok ekspresyon verisi başvurusu
Gen ontolojisi
Moleküler işlevi	• GO:0001105 transcription coactivator activity; • protein heterodimerization activity; • transmembrane signaling receptor activity; • protein homodimerization activity;
Hücresel bileşeni	• membrane; • sitoplazma; • alpha-beta T cell receptor complex; • integral component of membrane; • T cell receptor complex; • clathrin-coated vesicle membrane; • Hücre zarı; • external side of plasma membrane;
Biyolojik süreci	• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • regulation of immune response; • T cell receptor signaling pathway; • T cell differentiation; • positive thymic T cell selection; • cell surface receptor signaling pathway; • membrane organization; • protein homooligomerization; • adaptive immune response; • immune system process;
	Kaynaklar:Amigo / QuickGO
Ortologlar
	915
	12500
	ENSG00000167286
	ENSMUSG00000032094
	P04234
	P04235
	NM_001040651; NM_000732
	NM_013487
	NP_000723; NP_001035741
	NP_038515
	Vikiveri
İnsan'ı Gör/Düzenle	Fare'yi Gör/Düzenle

T hücresi yüzey glikoproteini CD3 delta zinciri, CD3D geni tarafından kodlanan bir insan proteinidir.^[4]

Etkileşimler değiştir

CD3D'nin CD8A ile etkileşime girdiği gösterilmiştir.^[5]

Ayrıca bakınız değiştir

CD3 (immünoloji)
Başkalaşım kümesi

Kaynakça değiştir

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167286 - Ensembl, May 2017
^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CD3D CD3d molecule, delta (CD3-TCR complex)". 5 Aralık 2010 tarihinde kaynağından arşivlendi.
^ Doucey (Jan 2003). "CD3 delta establishes a functional link between the T cell receptor and CD8". J. Biol. Chem. 278 (5). Amerika Birleşik Devletleri. ss. 3257-64.

Konuyla ilgili yayınlar değiştir

"Composition of TCR-CD3 complex in human intestinal intraepithelial lymphocytes: lack of Fc epsilon RI gamma chain". Int. Immunol. 7 (8). 1996. ss. 1237-41.
Li CJ (2007). "Therapeutic biology: checkpoint pathway activation therapy, HIV Tat, and transkingdom RNA interference". J. Cell. Physiol. 209 (3). ss. 695-700.
"Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon, delta proteins". J. Exp. Med. 175 (4). 1992. ss. 1055-66.
"The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope". Immunol. Lett. 33 (3). 1992. ss. 307-14.
"The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes". EMBO J. 10 (4). 1991. ss. 903-12.
"Cloning of a novel cell type from human fetal liver expressing cytoplasmic CD3 delta and epsilon but not membrane CD3". Int. Immunol. 3 (4). 1991. ss. 353-7.
"A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx". Cell. Immunol. 137 (1). 1991. ss. 1-13.
"Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway". J. Clin. Invest. 86 (6). 1991. ss. 2117-24.
"Immunoregulatory effect of a synthetic peptide corresponding to a region of protein p24 of HIV". Folia Biol. (Praha). 36 (1). 1990. ss. 71-7.
"The implications of subunit interactions for the structure of the T cell receptor-CD3 complex". Eur. J. Immunol. 20 (2). 1990. ss. 299-305.
"Dephosphorylation of the human T lymphocyte CD3 antigen". Eur. J. Biochem. 181 (1). 1989. ss. 55-65.
"Physical linkage of three CD3 genes on human chromosome 11". EMBO J. 6 (10). 1988. ss. 2953-7.
"Isolation and characterization of a cDNA clone encoding the murine homologue of the human 20K T3/T-cell receptor glycoprotein". Nature. 314 (6011). 1985. ss. 542-4.
"Exon/intron organization of the genes coding for the delta chains of the human and murine T-cell receptor/T3 complex". Proc. Natl. Acad. Sci. U.S.A. 83 (9). 1986. ss. 2944-8.
"Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family". Proc. Natl. Acad. Sci. U.S.A. 84 (21). 1987. ss. 7649-53.
"T3 delta pre-mRNA is transcribed from a non-TATA promoter and is alternatively spliced in human T cells". EMBO J. 5 (6). 1986. ss. 1245-52.
"Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex". Nature. 312 (5993). 1985. ss. 413-8.
"Costimulatory properties of the human CD4 molecule: enhancement of CD3-induced T cell activation by human immunodeficiency virus type 1 through viral envelope glycoprotein gp120". AIDS Res. Hum. Retroviruses. 9 (10). 1994. ss. 945-55. 17 Şubat 2020 tarihinde kaynağından arşivlendi. Erişim tarihi: 17 Şubat 2020.
"An HIV p24 heptapeptide down-regulates antigen-specific responses in vitro interfering at the level of the T3-Ti complex". Cell. Immunol. 156 (2). 1994. ss. 286-95.

Dış bağlantılar değiştir

Human CD3D genome location and CD3D gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: P04234 (T-cell surface glycoprotein CD3 delta chain) at the PDBe-KB.
PDBe-KB 23 Temmuz 2019 tarihinde Wayback Machine sitesinde arşivlendi. provides an overview of all the structure information available in the PDB for Human T-cell surface glycoprotein CD3 delta chain (CD3D)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167286 - Ensembl, May 2017

[2] "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: CD3D CD3d molecule, delta (CD3-TCR complex)". 5 Aralık 2010 tarihinde kaynağından arşivlendi.

[pmid12215456-5] Doucey (Jan 2003). "CD3 delta establishes a functional link between the T cell receptor and CD8". J. Biol. Chem. 278 (5). Amerika Birleşik Devletleri. ss. 3257-64.

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